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Friedman and coworkers concluded that compared with ipratropium alone or albuterol alone, ipratropium and albuterol improved FEV 1 and the FEV 1 AUC and reduced exacerbations and length of hospital stay, thereby reducing overall costs ().

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Memorial Sloan Kettering Cancer Center in New York, commented, "We have found that chronic obstructive pulmonary disease involves inflammatory processes.

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Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study.

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Respiratory Questionnaire (versus placebo), and reduced use of rescue medication (versus placebo and all monotherapies).

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Although inhalation therapy with hand-held inhalers is more common, nebulizers are also widely used.

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Adrenergic bronchodilators that are more selective for the beta 2-receptor and have a longer duration of action are preferred; therefore, epinephrine, isoetharine, and isoproterenol are generally not recommended for these indications.

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He also noted that the study was performed using hospital staff and funds and was not paid for by the pharmaceutical industry or the manufacturer of the device.

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Less medicine hits the throat when using a spacer device.

The aims of this investigation were to determine the prevalence of gastroesophageal reflux (GER) symptoms in COPD patients and the effect of GER on the rate of exacerbations of COPD per year.

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Patients with respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse were excluded.

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The findings of this study have been replicated with a similar study and, regardless of baseline characteristics, such as reversibility, smoking status, age, and lung function, the increases in Transitional Dyspnea Index and FEV 1 were greater with fluticasone and salmeterol than with ipratropium and albuterol ().

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Para facilitar la respiración, el médico prescribe medicamentos que relajen y descongestionen las vías respiratorias.

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Recent biopsy evidence of persistent inflammation and obstruction in the small airways of patients with COPD () raises the question of systemic delivery of bronchodilators.

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No tumorigenicity was observed in a 2-year study in rats given oral doses that provided 12 or 62 times the maximal daily human inhalational dose for the inhalation solution, or 23 or 114 times the maximal daily human dose for the metered-dose inhaler, or in an 18-month study in mice given oral doses that provided up to 312 times the maximal daily human inhalational dose for the inhalation solution, or 568 times the maximal daily human dose for the metered-dose inhaler.

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For example, the recent SMART trial of salmeterol in asthma was discontinued because of safety concerns ().

Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial.

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Inhalation by nebulization of albuterol-ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease.

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