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Friedman and coworkers concluded that compared with ipratropium alone or albuterol alone, ipratropium and albuterol improved FEV 1 and the FEV 1 AUC and reduced exacerbations and length of hospital stay, thereby reducing overall costs ().
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Memorial Sloan Kettering Cancer Center in New York, commented, "We have found that chronic obstructive pulmonary disease involves inflammatory processes.
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Respiratory Questionnaire (versus placebo), and reduced use of rescue medication (versus placebo and all monotherapies).
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Although inhalation therapy with hand-held inhalers is more common, nebulizers are also widely used.
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The aims of this investigation were to determine the prevalence of gastroesophageal reflux (GER) symptoms in COPD patients and the effect of GER on the rate of exacerbations of COPD per year.
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The findings of this study have been replicated with a similar study and, regardless of baseline characteristics, such as reversibility, smoking status, age, and lung function, the increases in Transitional Dyspnea Index and FEV 1 were greater with fluticasone and salmeterol than with ipratropium and albuterol ().
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Recent biopsy evidence of persistent inflammation and obstruction in the small airways of patients with COPD () raises the question of systemic delivery of bronchodilators.
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For example, the recent SMART trial of salmeterol in asthma was discontinued because of safety concerns ().
Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial.
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In the 6-mo open-label extension, there were fewer exacerbations and less need for reliever medication with adjustable-dose budesonide and formoterol.
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Long-acting anticholinergics (glycopyrrolate, which may work for up to 24 h in current formulations, and tiotropium) and LABAs (salmeterol and formoterol) have been combined with short-acting and long-acting agents from other classes.
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